Metabolic engineering and late-stage functionalization expand the chemical space of the antimalarial premarineosin A
Christina M. McBride, Morgan McCauley, Natalia R. Harris, S. Amin, Brian J. Curtis, Linnea Verhey-Henke, Awet Alem Teklemichael, Erin N. Oliphant, Patricia K. Dranchak, Katherine L. Lev, Fengrui Qu, Harrison M. Snodgrass, Jared C. Lewis, James Inglese, Xin‐zhuan Su, , David H. Sherman
This study uses metabolic engineering and late-stage functionalization to expand the chemical diversity of the antimalarial compound premarineosin A, identifying potent analogs.
Communications Chemistry · Dec 5, 2025Peer-reviewedMicrobiology