Mineralized Tissue-Targeting Expression System for Local Control of Gene Expression
Jingyi Liu, Qinyuan Chen, Il‐Chul Yoon, Hardik Makkar, Shilan Zhang, Yu‐Chang Chen, Yuantong Li, Jedtanut Thussananutiyakul, Lulu Xue, Shuchen Zhang, Junchao Xu, Yan Luo, Keyu Chen, Michael J. Mitchell, Chider Chen, Kyle H. Vining
This paper develops a gene expression system targeting mineralized tissues using bisphosphonate lipids, demonstrating enhanced RNA delivery and local therapeutic effects in bone regeneration and inflammation.
bioRxiv · Nov 25, 2025 · PreprintBioengineering