Giuseppe-Antonio Saldi

The paper identifies Pde10a as a regulator of neuronal excitability in SCN neurons, showing its rhythmic expression drives a depolarized silent state.

This study uses single-nucleus RNA-seq, ATAC-seq, and Multiome to analyze Alzheimer's disease across multiple brain regions, revealing shared and region-specific cellular vulnerabilities.

This study shows NM1 regulates adipose tissue remodeling, metabolic inflammation, and obesity in mice by controlling chromatin accessibility and gene expression during adipogenesis.

This study creates an integrated multimodal cell atlas of Alzheimer's disease by analyzing single nuclei transcriptomes, epigenomes, and spatial coordinates across AD stages.

MultiVI integrates multi-modal single-cell data by creating a joint representation and imputing missing values while correcting batch effects.

The paper introduces Inferelator 3.0, a tool for inferring gene regulatory networks from single-cell data, showing improved performance on yeast and mouse brain datasets.

The paper identifies cell-type specific circuits formed by subtypes of somatostatin interneurons in the cortex through genetic targeting and connectivity analysis.

This paper introduces DEWAKSS, a method for denoising single-cell genomics data by optimally tuning kNN- and diffusion-based approaches to preserve biological variance and improve clustering.

The paper identifies enhancers for targeting specific neuronal subtypes across species and demonstrates their utility in circuit manipulation.

The paper develops a method to reconstruct gene regulatory networks from scRNA-seq data by barcoding gene deletion mutants in budding yeast across diverse environments.