NeurosciencebioRxivPreprint
Psychedelic compounds directly excite 5-HT2A Layer 5 Pyramidal Neurons in the Prefrontal Cortex through a 5-HT2A Gq-mediated activation mechanism
Gavin P. Schmitz, Yi-Ting Chiu, Gabriele Maria König…·Melissa A. Herman
This study shows psilocin excites 5-HT2A Layer 5 Pyramidal Neurons in the mouse PFC via a Gq-mediated mechanism, increasing firing without affecting synaptic transmission.
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