Author

Gavin P. Schmitz

University of North Carolina at Chapel Hill

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Neuroscience· 4

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:mouse· 3 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Assay:electronic health records· 1 Organism:human· 1 Assay:proteomics· 1 Approach:statistical model· 1

Frequent Co-Authors

Bryan L. RothiD· 3 shared Melissa A. HermaniD· 2 shared Yi-Ting ChiuiD· 2 shared Ariel Y. Deutch· 1 shared Bei LiuiD· 1 shared Brandon J. AragonaiD· 1 shared Chongguang CheniD· 1 shared D. Dewran KoçakiD· 1 shared

Activity by Year

2018-2026 · peak 1/yr

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10 top collaborators · 28 mutual co-author links

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3 shared papersNeuroscience

Bryan L. RothORCID

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4 papers

Recent·Most cited

A suite of engineered mice for interrogating psychedelic drug actions

Yi-Ting Chiu, Ariel Y. Deutch, Wei Wang, Gavin P. Schmitz, Karen Lu Huang, D. Dewran Koçak, Pierre Llorach, Kasey Bowyer, Bei Liu, Noah Sciaky, Kunjie Hua, Chongguang Chen, S. Mott, Jesse K. Niehaus, Jeffrey F. DiBerto, , Bryan L. Roth

This paper introduces engineered mouse models to study the effects of psychedelic drugs by examining HTR2A receptor expression and function.

Nature Neuroscience · Aug 6, 2026Peer-reviewedNeuroscience

Psychedelic compounds directly excite 5-HT2A Layer 5 Pyramidal Neurons in the Prefrontal Cortex through a 5-HT2A Gq-mediated activation mechanism

Gavin P. Schmitz, Yi-Ting Chiu, Gabriele Maria König, Evi Kostenis, Bryan L. Roth, Melissa A. Herman

This study shows psilocin excites 5-HT2A Layer 5 Pyramidal Neurons in the mouse PFC via a Gq-mediated mechanism, increasing firing without affecting synaptic transmission.

bioRxiv · Nov 15, 2022 · PreprintNeuroscience

Pharmacologic analysis of non-synonymous coding 5-HT2A SNPs reveals alterations psychedelic drug potencies and efficacies

Gavin P. Schmitz, Manish Kumar Jain, Samuel T. Slocum, Bryan L. Roth

The paper examines how non-synonymous SNPs in the 5-HT2A receptor gene affect the potency and efficacy of four psychedelic drugs in vitro.

bioRxiv · Dec 9, 2021 · PreprintNeuroscience

In vivo detection of optically-evoked opioid peptide release

Ream Al‐Hasani, Jenny‐Marie T. Wong, Omar S. Mabrouk, Jordan G. McCall, Gavin P. Schmitz, Kirsten A. Porter‐Stransky, Brandon J. Aragona, Robert T. Kennedy, Michael R. Bruchas

The paper develops a system to measure opioid peptide release in vivo using optogenetics, microdialysis, and mass spectrometry in freely moving rodents.

eLife · Sep 3, 2018Peer-reviewedNeuroscience