David W. Sosnowski

This study uses human iPSC-derived prefrontal cortex organoids to show that THC exposure disrupts neurodevelopmental gene expression and epigenetic regulation, linking these changes to autism risk genes.

This study examines how ambient temperature during pregnancy affects newborn birthweight, finding higher temperatures in the third trimester linked to increased birthweight, especially in male infants.

The paper compares gene expression in the prefrontal cortex between individuals who died from acute opioid intoxication and controls, finding NPAS4 is downregulated and associated with opioid use.

This study examines DNA methylation in brain tissue from opioid users and controls, finding a significant association between opioid use and phenotypic age but no genome-wide significant CpG sites.