Chang Shu

This study identifies microglia as key contributors to senescence in Alzheimer's disease, linking cholesterol dysregulation to senescence pathologies through transcriptomic analysis of multiple datasets.

The paper identifies 60 new moderate risk genes for autism by integrating de novo and inherited variants across 42,607 cases and 236,000 controls.

The paper compares gene expression in the prefrontal cortex between individuals who died from acute opioid intoxication and controls, finding NPAS4 is downregulated and associated with opioid use.

This study examines DNA methylation in brain tissue from opioid users and controls, finding a significant association between opioid use and phenotypic age but no genome-wide significant CpG sites.

The paper predicts cellular positions in the Drosophila embryo using scRNA-seq data by benchmarking methods against spatially annotated genes.

This study identifies 294 genes affected by acute THC administration in human immune cells, including 69 common and 225 cell-type specific genes.