Amy Deep‐Soboslay

The paper uses spatial transcriptomics to analyze molecular differences in mood disorders and biological sex in the human prefrontal cortex, identifying sex- and disorder-specific gene expression patterns.

This study maps the spatiomolecular organization of the human habenula using multi-omic approaches, identifying molecular signatures and spatial domains linked to psychiatric disorders.

The paper identifies 46,802 enhancers and 164 psychiatric disorder variants with regulatory effects in the developing cortex and organoids using massively parallel reporter assays and deep learning.

The paper generates a molecular neuroanatomical map of the human prefrontal cortex using spatial transcriptomics and single nucleus RNA-sequencing, revealing novel spatial domains and cell-cell interactions linked to psychiatric disorders.

The paper identifies differentially expressed genes in PTSD and MDD across brain regions, highlighting shared and unique transcriptional patterns and immune-related pathways.

The paper compares gene expression in the prefrontal cortex between individuals who died from acute opioid intoxication and controls, finding NPAS4 is downregulated and associated with opioid use.

This study examines DNA methylation in brain tissue from opioid users and controls, finding a significant association between opioid use and phenotypic age but no genome-wide significant CpG sites.

This study identifies DNA methylation differences in the nucleus accumbens of smokers versus nonsmokers, revealing both shared and tissue-specific CpGs associated with smoking.

The paper identifies regional differences in gene expression and regulation in hippocampus and dorsolateral prefrontal cortex across development and in schizophrenia using RNA-seq data from 900 samples.

The paper uses LCM-seq to profile gene expression in the human dentate gyrus granule cell layer, identifying cell type-specific genetic effects and novel schizophrenia-associated variants not detected in bulk RNA-seq.

The paper identifies differentially methylated DNA sites and associated genes in Alzheimer’s disease across multiple brain regions, linking them to gene expression and biological processes.

The paper replicates a postmortem association of LINC01268 with violent suicide and links it to in vivo aggression and prefrontal cortex function in living individuals.

This study identifies gene expression changes in the prenatal human cortex due to maternal smoking and links them to neuropsychiatric disorder risk genes.

The paper identifies 237 genes associated with schizophrenia using RNA sequencing and eQTL analysis, showing enrichment for developmentally regulated synaptic genes.