Jonathan L. Golob

The paper shows that transient inflammation generates protective Th17 cells that work with trained microbiota to protect against intestinal injury.

This paper investigates how acarbose affects two Bacteroides species, showing that Bt growth is inhibited while Bo growth is not, revealing complex mechanisms involving Sus system interactions and differential gene expression.

This paper harmonizes microbiome studies by placing amplicon sequence variants (ASV) on a common phylogenetic tree, improving community relationship accuracy compared to closed-OTU methods.

The paper introduces a tool for gene-level metagenomic analysis to identify genomic islands linked to immunotherapy response in microbiome data.

The paper benchmarks metagenomic tools for coding sequence detection, finding that assembly-based methods have high PPV but low sensitivity at low coverage, while mapping-based methods are more sensitive but struggle with PPV.

The paper co-cultures Bifidobacterium longum with human colonic epithelium and finds reduced inflammation and changes in gene expression related to barrier function and cellular energetics.