Author

Adrian J. Lloyd

University of WarwickORCID 0000-0002-4638-4586Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:drug response / drug discovery· 1 Organism:E. coli· 1

Frequent Co-Authors

David I. RoperiD· 2 shared Catherine E RowlandiD· 1 shared Celia KessleriD· 1 shared Christopher Gerard DowsoniD· 1 shared Dom BelliniiD· 1 shared Hector NewmaniD· 1 shared James M. WagstaffiD· 1 shared Katerine Van RietschoteniD· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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2 shared papersBiochemistry

David I. RoperORCID

Mutual co-authors in cluster

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2 papers

Recent·Most cited

Discovery and chemical optimisation of a Potent, Bi-cyclic (Bicycle(R)) Antimicrobial Inhibitor of Escherichia coli PBP3

Catherine E Rowland, Hector Newman, Tazmin T. Martin, Rachel Dods, Nikolaos Bournakas, James M. Wagstaff, Nick Lewis, Steven J. Stanway, Matthew R. Balmforth, Celia Kessler, Katerine Van Rietschoten, Dom Bellini, David I. Roper, Adrian J. Lloyd, Christopher Gerard Dowson, , Michael J. Dawson

This study discovers and optimizes bicyclic peptide inhibitors of E. coli PBP3, showing high-affinity binding and broad-spectrum antimicrobial activity.

Communications Biology · May 28, 2025Peer-reviewedBiochemistry

Uncovering the Biological Function of the Peptidoglycan Hydrolase PcsB in Streptococcus pneumoniae

Nicholas S Briggs, Kevin E. Bruce, Stefano Camaione, Souvik Naskar, Adrian John Lloyd, Malcolm E. Winkler, David I. Roper

This study identifies the enzymatic function of PcsB, a peptidoglycan hydrolase in Streptococcus pneumoniae, showing it cleaves Lys-containing, amidated peptidoglycan and is regulated by structural changes.

bioRxiv · May 23, 2025 · PreprintBiochemistry