Hector Newman

The paper identifies and optimizes bicyclic peptide inhibitors of Staphylococcus aureus α-hemolysin, achieving sub-micromolar affinity and demonstrating functional inhibition of toxin activity.

This paper identifies a novel open state of the LptDE translocon bound by a phage RBP, revealing potential for peptidomimetic inhibition and insights into phage resistance mechanisms.

This study discovers and optimizes bicyclic peptide inhibitors of E. coli PBP3, showing high-affinity binding and broad-spectrum antimicrobial activity.