Kai Blin

The paper develops a computational pipeline and database to annotate halogenating enzymes in genomic and metagenomic data, revealing underexplored clusters and improving predictions of microbial halogenated natural products.

metaSMASH improves BGC detection in large metagenomes by reducing computational cost while maintaining result accuracy.

PhyloNaP provides a database of phylogenetic trees for biosynthetic enzymes, enabling functional inference and community contributions.

This paper introduces a method using protein language models to construct pangenomes, achieving better cluster quality and functional consistency than existing tools.

epsSMASH identifies exopolysaccharide biosynthetic gene clusters in environmental and human microbiomes, revealing widespread uncharacterized clusters.

StreptoCAD automates genome engineering workflows in Streptomyces, streamlining design, simulation, and documentation of CRISPR-based and overexpression strategies.

The paper introduces the BGC Atlas, a web resource that explores BGC diversity in metagenomes, identifying nearly 1.8 million BGCs and showing RiPPs as the most abundant compound class.

The paper provides over 1,000 high-quality Actinomycetia genomes, revealing genomic structures and biosynthetic gene cluster organization with ecological and biotechnological implications.

The paper develops CRISPR-BEST, a DSB-free base editing system for filamentous actinomycetes, achieving single-nucleotide resolution in Streptomyces species.

plantiSMASH identifies and analyzes plant biosynthetic gene clusters using genomic and transcriptomic data to prioritize candidates and study their evolutionary conservation.