Mukul Tewary

The paper uses a computational model and experiments to show that small micro-patterned mPSC colonies exhibit spontaneous asymmetry in BRA-GFP patterns, suggesting a mechanism for symmetry-breaking in development.

The paper develops a GRN model embedded in cellular agents to simulate hPSC lineage commitment and shows how GRN wiring influences germ layer pattern formation.

The paper develops an in vitro platform to study fate patterning in hPSCs, revealing Nodal-dependent switches between gastrulation and neurulation-associated gene profiles.

The paper integrates genetic and cell biological data from human iPSC lines to identify intrinsic and extrinsic factors driving inter-individual variability in cell behavior.

The paper develops a high-throughput assay to study peri-gastrulation-like fate patterning in human pluripotent stem cells, revealing coordination between Reaction-Diffusion and Positional-Information mechanisms.