Ross D. Jones

The paper shows that gene syntax influences supercoiling-mediated transcriptional feedback, affecting adjacent gene expression in human cells.

This study shows how to generate CD4+ T cells from pluripotent stem cells by controlling Notch and T cell receptor signaling, enabling clonally diverse and expandable cells that can differentiate into helper cell types.

The paper identifies OCT4 trajectories critical for reprogramming human fibroblasts to iPSCs and develops a synthetic genetic circuit to enforce these trajectories, improving reprogramming efficiency.

The paper develops a GRN model embedded in cellular agents to simulate hPSC lineage commitment and shows how GRN wiring influences germ layer pattern formation.

This paper develops synthetic phosphorylation-based signaling networks in mammalian cells that are tunable, precise, and robust to perturbations.

The paper develops synthetic gene circuits in human pluripotent stem cells that convert discrete cell states into analog signals by integrating miRNAs with miSFITs for controlled effector protein production.

This paper develops an endoribonuclease-based feedforward loop to improve modularity in genetic systems by reducing resource competition in mammalian cells.