Alexander Arthur Wurm

Systematic functional drug testing in patient-derived models reveals ex vivo sensitivities associated with clinical outcome in rare solid tumors

This study develops an ex vivo drug sensitivity testing platform for rare solid tumors and finds that high in vitro sensitivity correlates with clinical benefit and progression-free survival.

Myeloid cell-mediated killing of B-ALL by CD38 and CD20IgA antibody variants is enhanced by CD47/SIRPα interference

This study evaluates the efficacy of CD38 and CD20 IgG1/IgA2 antibodies in mediating myeloid cell-mediated killing of B-ALL, showing enhanced activity with CD47/SIRPα blockade.

Mesenchymal-epithelial transition reduces proliferation but increases immune evasion in tumor spheroids

This study shows that mesenchymal-epithelial transition (MET) in breast cancer cells reduces proliferation but enhances immune evasion, suggesting MET promotes tumor outgrowth through immune survival rather than proliferation.