SAD-6/ATRX enables broad genome surveillance and defense in fungi
Florian Carlier, Anna Klimova, Eléonore Bouscasse, Ziyan Wang, Isabelle Loïodice, Angela Taddei, Ilkka Kronholm, Jay Dunlap, Mariette Matondo, Eugene A. Gladyshev
This paper shows that the fungal ATRX ortholog SAD-6 uses a unique histone H4 variant for genome surveillance and defense, revealing its role in various genomic regions and a repeat-induced point mutation pathway.
bioRxiv · Aug 11, 2026 · PreprintMolecular Biology