ImmunologyeLifePeer-reviewed
DGKα and ζ Deficiency Causes Regulatory T-Cell Dysregulation, Destabilization, and Conversion to Pathogenic T-Follicular Helper Cells to Trigger IgG1-Predominant Autoimmunity
Lei Li, Hongxiang Huang, Hongxia Wang…·Xiao‐Ping Zhong
This study shows that DGKα and ζ deficiency in Tregs leads to their dysfunction, conversion to pathogenic Tfh cells, and triggers IgG1-predominant autoimmunity.
3 citations