Author

Kirk James McManus

University of ManitobaORCID 0000-0003-0081-8737Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

Click to filter author papers

Cell Biology· 2 Cancer Biology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Organism:mouse· 3 Assay:proteomics· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:cell type annotation· 2 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:development & morphogenesis· 1 Assay:DNA methylation· 1 Approach:experimental assay· 1

Frequent Co-Authors

Ayesha SaleemiD· 2 shared Joseph W. GordoniD· 2 shared Patience O. ObiiD· 2 shared Tamiris de Fátima Goebel de SouzaiD· 2 shared Adrian Robert WestiD· 1 shared Anas K. Gremida· 1 shared Anuj Shukla· 1 shared Chien Huan Chen· 1 shared

Activity by Year

2024-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

2 shared papersCell Biology

Ayesha SaleemORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Cell BiologybioRxivPreprintMay 27, 2026

Fasting disrupts the InsP6 HDAC3 axis to drive ER stress-mediated clearance of DNA-damaged cells and enforce tissue quality control.

Sujan Chetterjee, Zachary Sin, Richard Van…·Prasun Guha

The paper shows that fasting disrupts the TGF-β-InsP6-HDAC3 axis, inducing ER stress and eliminating DNA-damaged cells to maintain tissue quality.

DOI 10.64898/2026.05.24.727426

mouseproteomics

𝕏 PostBluesky

Cell BiologybioRxivPreprintSep 9, 2024

Identification of novel myokines and putative protein targets that mediate functional adaptations in response to chronic contractile activity induced skeletal muscle-extracellular vesicle treatment

Patience O. Obi, Tamiris F. G. Souza, Ying Lao…·Ayesha Saleem

The paper identifies novel proteins and pathways in skeletal muscle-derived extracellular vesicles following chronic contractile activity, suggesting their role in metabolic and anti-tumorigenic effects.

2 citations

mouseproteomics

𝕏 PostBluesky

Cancer BiologybioRxivPreprintAug 29, 2024

The pro-apoptotic effect of chronic contractile activity-induced extracellular vesicles on Lewis Lung Carcinoma cells

Patience O. Obi, Tamiris de Fátima Goebel de Souza, Kirk James McManus…·Ayesha Saleem

This study shows that chronic contractile activity-induced skeletal muscle-derived extracellular vesicles reduce LLC cell viability and induce apoptosis and senescence.

3 citations

mouseproteomics

𝕏 PostBluesky