Jean Albert Ouellet

This paper develops a standardized in vitro model for senolytic drug screening using human intervertebral disc cells and validates a metabolic activity assay as a scalable method to assess senolytic activity.

This study shows that combining chemotherapeutic drugs with senolytics reduces senescent cells and tumor growth in breast cancer models.

This study shows that combining Doxorubicin with senolytics reduces senescence and tumor growth in 3D models of bone metastasis.

The paper identifies anti-inflammatory miRNAs in extracellular vesicles from human intervertebral disc cells and shows their synergistic effects in reducing inflammation and promoting regeneration.

This study shows that early senolytic treatment prevents low back pain in mice by reducing senescence markers and inflammation in spinal tissues.

Senolytic drugs reduce low back pain by eliminating senescent cells and decreasing inflammatory factors in the intervertebral disc and spinal cord.

This study uses single-cell RNA sequencing to analyze spinal cord microglia responses to nerve injury, identifying sex- and time-specific changes and a role for ApoE in neuropathic pain.