Livia Garzia

Ependymomas are cancers of the pre-neural crest/roof plate lineage

The paper identifies ependymomas as originating from the pre-neural crest/roof plate lineage using single-cell transcriptomics and lineage tracing.

Targeting therapy-induced senescence across multiple breast cancer subtypes in a metastatic bone-like microenvironment

This study shows that combining chemotherapeutic drugs with senolytics reduces senescent cells and tumor growth in breast cancer models.

Targeting breast cancer senescence in 3D models of bone metastasis

This study shows that combining Doxorubicin with senolytics reduces senescence and tumor growth in 3D models of bone metastasis.

Ras-Responsive Element Binding Protein 1 regulates survival of Group 3 medulloblastoma

This study identifies RREB1 as a key driver of Group 3 medulloblastoma, showing its role in tumor growth and survival through the c-MET signaling pathway.

Synapse-specific diversity of distinct postsynaptic GluN2 subtypes defines transmission strength in spinal lamina I

The paper investigates synapse-specific diversity of GluN2 subunits in spinal lamina I neurons and shows how they differentially tune depolarization events.

Childhood cerebellar tumors mirror conserved fetal transcriptional programs

The paper uses single-cell transcriptomics to show childhood cerebellar tumors mirror fetal cerebellar cell lineages, linking tumor subtypes to specific developmental stages.