ImmunologybioRxivPreprint
Nuclear stiffening in neoplastic cells aggregates T cell exhaustion via pFAK/SP1/IL-6 axis in colorectal cancer
Hao Kong, Xiangji Wu, Qingxin Yang…·Hong Jiang
The paper shows that nuclear stiffening in colorectal cancer cells promotes T cell exhaustion through the pFAK/SP1/IL-6 axis, and inhibiting pFAK improves antitumor immunity.
DOI 10.1101/2024.07.24.604770