Nuclear stiffening in neoplastic cells aggregates T cell exhaustion via pFAK/SP1/IL-6 axis in colorectal cancer
Hao Kong, Xiangji Wu, Qingxin Yang, Qian Sun, Xin Yu, Yu Dai, Chun-Wei George Wu, Dai Xie, Lang Chen, Panpan Ma, Siqi Dai, Chong Chen, Peng Mi, Xiaodong Feng, Yong Li Peng, , Hong Jiang
The paper shows that nuclear stiffening in colorectal cancer cells promotes T cell exhaustion through the pFAK/SP1/IL-6 axis, and inhibiting pFAK improves antitumor immunity.
bioRxiv · Jul 24, 2024 · PreprintImmunology