Author

Michal Irony‐Tur Sinai

Hebrew University of JerusalemORCID 0000-0003-0126-473XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Genetics· 2 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Organism:human· 3 Approach:experimental assay· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Research Focus:genome assembly· 1

Frequent Co-Authors

Batsheva KeremiD· 3 shared Alexandra Eliassaf· 1 shared Anita GoleciD· 1 shared Aurélie ErnstiD· 1 shared Aurélie HattoniD· 1 shared Brian MagnusoniD· 1 shared Chen LeibsoniD· 1 shared Dan SarniiD· 1 shared

Activity by Year

2019-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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3 shared papersGenetics

Batsheva KeremORCID

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3 papers

Recent·Most cited

Cancer BiologybioRxivPreprintApr 17, 2025

P53 deficiency triggers hypertranscription, inducing nucleotide insufficiency causing replication stress, and genomic instability

Wisam Zaatra, George Philippos, Petr Smirnov…·Aurélie Ernst

This study shows that p53 deficiency causes hypertranscription and nucleotide insufficiency, leading to replication stress and genomic instability, including chromothripsis.

1 citation

humanexperimental assay

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GeneticsJournal of Cystic FibrosisPeer-reviewedJul 2, 2021

Antisense oligonucleotide-based drug development for Cystic Fibrosis patients carrying the 3849+10kb C-to-T splicing mutation

Yifat S. Oren, Michal Irony‐Tur Sinai, Anita Golec…·Batsheva Kerem

This study develops an antisense oligonucleotide (ASO) therapy for CF patients with the 3849+10kb C-to-T splicing mutation, showing restoration of CFTR function in patient-derived cells.

55 citationstop 2%

humanexperimental assay

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GeneticsbioRxivPreprintJul 28, 2019

Replication Timing and Transcription Identifies a Novel Fragility Signature Under Replication Stress

Dan Sarni, Takayo Sasaki, Karin Miron…·Batsheva Kerem

The paper identifies a fragility signature linked to replication stress and transcription in chromosomal instability by analyzing replication timing and gene expression.

7 citations

humanbulk RNA-seq

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