Andrew P. Voigt

Transcriptomic Characterization of Terminal Complement Complex-bound Cells in Human Choroid Using Single-Cell RNA Sequencing

This study uses single-cell RNA sequencing to analyze MAC-bound cells in human choroid, revealing patterns of complement deposition and regulator expression in AMD.

Single-cell quantitative trait loci analyses identify expression changes in macular degeneration risk genes

The paper identifies expression changes in AMD risk genes using single-cell eQTL analysis across AMD stages and tissues.

GENE EXPRESSION WITHIN A HUMAN CHOROIDAL NEOVASCULAR MEMBRANE USING SPATIAL TRANSCRIPTOMICS

This study uses spatial transcriptomics to analyze gene expression in a human choroidal neovascular membrane and identifies dysregulated genes and potential upstream regulators.

Loss of NR2E3 disrupts rod photoreceptor cell maturation causing a fate switch late in human retinal development.

This study uses human retinal organoids to show that loss of NR2E3 disrupts rod photoreceptor maturation, leading to a fate switch to cone-like cells.

Multimodal single-cell analysis of non-random heteroplasmy distribution in human retinal mitochondrial disease

The paper uses multimodal single-cell sequencing to show non-random distribution of a pathogenic mtDNA variant in retinal cells of a MELAS patient.

A simplified transposon mutagenesis method to perform phenotypic forward genetic screens in cultured cells

This paper introduces a simplified transposon mutagenesis method for phenotypic forward genetic screens in cultured cells, demonstrating high reproducibility across independent replicates.