Edwin M. Stone

This study uses single-cell RNA sequencing to analyze MAC-bound cells in human choroid, revealing patterns of complement deposition and regulator expression in AMD.

This paper develops a targeted choroidal injury model in rats using saporin-conjugated antibodies and compares it to systemic sodium iodate administration, showing localized injury with fewer side effects.

The paper identifies expression changes in AMD risk genes using single-cell eQTL analysis across AMD stages and tissues.

This study analyzes metabolites in human retinal pigment epithelium and choroid tissue across aging and macular degeneration stages, identifying key metabolic changes associated with aging.

This study evaluates polyurethane nanocapsules delivering Acriflavine for treating CNVM in a rat model, showing reduced CNVM size and incidence compared to controls.

This study develops a xeno-free 3D retinal differentiation protocol for iPSCs to generate transplantable photoreceptor cells in a cGMP-compliant manner.

This paper describes a method to isolate photoreceptor cells from retinal organoids without specialized equipment, using standard lab materials for potential clinical applications.

This study examines sialoglycoconjugates in human choroid and macular degeneration lesions using lectins to identify sialic acid types and their distribution.

The paper identifies a splice defect caused by the NR2E3 c.932G>A variant in retinal disease, challenging previous assumptions about its molecular mechanism.

This paper develops self-healing hydrogels to support choroidal endothelial cell transplantation in a rat model, showing improved cell retention compared to cell suspensions.

This study uses spatial transcriptomics to analyze gene expression in a human choroidal neovascular membrane and identifies dysregulated genes and potential upstream regulators.

This study uses human retinal organoids to show that loss of NR2E3 disrupts rod photoreceptor maturation, leading to a fate switch to cone-like cells.

The paper uses multimodal single-cell sequencing to show non-random distribution of a pathogenic mtDNA variant in retinal cells of a MELAS patient.

The paper identifies genetic modifiers of CEP290-mediated retinal degeneration in mice using QTL analysis and genetic crosses.

This study uses iPSC-RPE models to evaluate gene augmentation and editing for Best disease, finding that some mutations respond to gene therapy while others require genome editing.