Anthony M. Downs

Loss of excitatory inputs and decreased tonic and evoked activity of locus coeruleus neurons in aged P301S mice

This study examines electrophysiological changes in locus coeruleus neurons of aged P301S mice, finding reduced excitatory inputs and neuronal activity linked to tau pathology.

Oral Fentanyl Consumption and Withdrawal Impairs Fear Extinction Learning and Enhances Basolateral Amygdala Principal Neuron Excitatory-Inhibitory Balance in Male and Female Mice

This study shows that oral fentanyl consumption in mice leads to impaired fear extinction and altered neural excitability in the basolateral amygdala, with sex-specific behavioral effects.

Diverse ancestral brainstem noradrenergic neuron activity across species and biological factors

This study analyzes LC neuron firing patterns across species and biological factors, revealing diverse activity patterns and subregions enriched for specific factors and disease models.

Lgr5+ ductal cells of von Ebner's glands are stem cells for turnover of posterior tongue taste buds

Tauopathy and alcohol consumption interact to alter locus coeruleus excitatory transmission and excitability in male and female mice

This study examines how tauopathy and alcohol consumption interact to alter locus coeruleus neuron excitability in mice, finding significant changes in excitatory inputs and excitability due to both factors.

Effects of Long-Term Alcohol Consumption on Behavior in the P301S (Line PS19) Tauopathy Mouse Model

This study examines how long-term alcohol consumption affects behavior in a tauopathy mouse model, finding significant interactions between alcohol exposure and genotype that vary by sex.