Luke A. Wykoff

Xylazine and fentanyl co-administration delays wound healing in mice

This study shows that xylazine and fentanyl co-administration in mice delays wound healing, while neither drug alone does so at tested doses.

Loss of excitatory inputs and decreased tonic and evoked activity of locus coeruleus neurons in aged P301S mice

This study examines electrophysiological changes in locus coeruleus neurons of aged P301S mice, finding reduced excitatory inputs and neuronal activity linked to tau pathology.

β-arrestin-biased Allosteric Modulator of Neurotensin Receptor 1 Reduces Ethanol Drinking and Responses to Ethanol Administration in Rodents

This study evaluates the effects of SBI-553, a β-arrestin-biased allosteric modulator of NTSR1, on ethanol-related behaviors in rodents, finding reduced ethanol consumption and altered sensitivity to ethanol effects.

GABA Release From Central Amygdala Neurotensin Neurons Differentially Modulates Reward and Consummatory Behavior in Male and Female Mice

This study shows that reducing GABA release from central amygdala neurotensin neurons decreases alcohol drinking in male mice but not females, with distinct behavioral effects in each sex.