Developmental BiologyMolecular Human ReproductionPeer-reviewed
An Nlrp5-null mutation leads to attenuated de novo methylation in oocytes, accompanied by a significant reduction in DNMT3L
Leah Nic Aodha, Alexandra V. Pokhilko, Leah U. Rosen…·Gavin Kelsey
This study shows that Nlrp5-null oocytes have reduced DNMT3L and impaired de novo methylation, leading to imprinting disorders and developmental issues.
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