Author

Christian Belton

Babraham InstituteORCID 0000-0002-4414-9988Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Assay:DNA methylation· 2 Approach:experimental assay· 2 Organism:mouse· 2 Assay:bulk RNA-seq· 1 Assay:ChIP-seq· 1 Research Focus:differential expression· 1 Research Focus:gene regulatory network inference· 1 Approach:statistical model· 1

Frequent Co-Authors

Gavin KelseyiD· 2 shared A Francis Stewart· 1 shared Alexandra V. PokhilkoiD· 1 shared Andrea KranziD· 1 shared Andreas DahliD· 1 shared António Miguel GalvãoiD· 1 shared Asif NakhudaiD· 1 shared Bill Mansfield· 1 shared

Activity by Year

2022-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersDevelopmental Biology

Gavin KelseyORCID

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2 papers

Recent·Most cited

Developmental BiologyMolecular Human ReproductionPeer-reviewedJan 1, 2025

An Nlrp5-null mutation leads to attenuated de novo methylation in oocytes, accompanied by a significant reduction in DNMT3L

Leah Nic Aodha, Alexandra V. Pokhilko, Leah U. Rosen…·Gavin Kelsey

This study shows that Nlrp5-null oocytes have reduced DNMT3L and impaired de novo methylation, leading to imprinting disorders and developmental issues.

1 citation

mouseDNA methylation

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Developmental BiologyNucleic Acids ResearchPeer-reviewedJan 25, 2022

Loss of histone methyltransferase SETD1B in oogenesis results in the redistribution of genomic histone 3 lysine 4 trimethylation

Courtney W. Hanna, Jiahao Huang, Christian Belton…·Gavin Kelsey

This study shows that loss of SETD1B in oocytes causes redistribution of H3K4me3, with loss at active promoters and gain at CpG-rich regions, revealing distinct roles for SETD1B and MLL2 in epigenetic regulation.

36 citations

mouseChIP-seq

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