Leah U. Rosen

An Nlrp5-null mutation leads to attenuated de novo methylation in oocytes, accompanied by a significant reduction in DNMT3L

This study shows that Nlrp5-null oocytes have reduced DNMT3L and impaired de novo methylation, leading to imprinting disorders and developmental issues.

Sensitive cluster-free differential expression testing.

The paper introduces miloDE, a cluster-free method for differential expression testing in single-cell RNA sequencing data, improving sensitivity and specificity by avoiding discrete clustering.

A reference induced pluripotent stem cell line for large-scale collaborative studies

The paper identifies and characterizes a reference iPSC line, KOLF2.1J, for standardized use in collaborative studies across multiple differentiation protocols and assays.

Inter-gastruloid heterogeneity revealed by single cell transcriptomics time course: implications for organoid based perturbation studies

The paper uses single-cell RNA-sequencing to study heterogeneity in mouse gastruloids over time, revealing distinct mesodermal and neural differentiation trajectories and their implications for perturbation studies.