Author

Tyler J. Reich

University of Wisconsin–MadisonORCID 0000-0003-0178-1411Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Molecular Biology· 1

Signature Assays, Organisms & Methods

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Assay:ChIP-seq· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1 Organism:human· 1 Research Focus:protein structure prediction· 1

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Andrew Q. RashoffiD· 1 shared Audrey BaguetteiD· 1 shared Benjamin Aaron GarciaiD· 1 shared Caterina RussoiD· 1 shared Claudia L. KleinmaniD· 1 shared Joanna K. LempiäineniD· 1 shared Nada JabadoiD· 1 shared Paul A. ClarkiD· 1 shared

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Andrew Q. RashoffORCID

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1 paper

Recent·Most cited

Molecular BiologybioRxivPreprintJul 18, 2025

SUZ12-Nucleic Acid Interactions Constrain PRC2 Activity to Maintain Targeted Gene Silencing Essential to Diffuse Midline Glioma

Tyler J. Reich, Paul A. Clark, Audrey Baguette…·Peter W. Lewis

The paper identifies SUZ12's nucleic acid-binding domain as critical for regulating PRC2 activity in H3 K27M gliomas, showing how it constrains enzymatic function and maintains targeted gene silencing.

1 citation

humanChIP-seq

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