George Hunt

Catalytic-dependent and independent functions of the histone acetyltransferase CBP promote pioneer factor-mediated zygotic genome activation

This study shows that CBP, a histone acetyltransferase, has both catalytic and non-catalytic roles in zygotic genome activation, independent of its acetylation function.

Comprehensive interrogation of a Drosophila embryonic patterning network reveals the impact of chromatin state on tissue-specific burst kinetics and RNA Polymerase II promoter-proximal pause release

The paper investigates how chromatin state influences transcriptional burst kinetics and RNA Polymerase II pausing during Drosophila embryonic patterning.

The control of transcriptional memory by stable mitotic bookmarking

This study shows that the transcription factor GAF acts as a stable mitotic bookmark during zygotic genome activation in Drosophila embryos, enabling rapid transcriptional activation after mitosis.