Author

Anuran Kumar Gayen

University of FloridaORCID 0000-0003-0231-417XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:Arabidopsis· 1 Organism:bacteria (other)· 1 Research Focus:protein design· 1 Assay:protein sequence· 1

Frequent Co-Authors

Andrew D. HansoniD· 2 shared A. Harvey MillariD· 1 shared Bryan J. LeongiD· 1 shared Edmar R. Oliveira-FilhoiD· 1 shared Katharina BeltiD· 1 shared Kristen Van GelderiD· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

6 top collaborators · 11 mutual co-author links

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2 shared papersSynthetic Biology

Andrew D. HansonORCID

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2 papers

Recent·Most cited

Synthetic BiologybioRxivPreprintJul 1, 2025

Continuous Directed Evolution of a Plant Histidinol Dehydrogenase to Extend Lifespan

Edmar R. Oliveira-Filho, Anuran Kumar Gayen, Bryan J. Leong…·Andrew D. Hanson

This study uses directed evolution to extend the lifespan of an Arabidopsis enzyme by increasing its abundance and improving its resistance to a toxic intermediate.

2 citations

Arabidopsisprotein sequence

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Synthetic BiologyPlant Biotechnology JournalPeer-reviewedJan 3, 2025

Mirages in continuous directed enzyme evolution: A cautionary case study with plantized bacterial THI4 enzymes

Kristen Van Gelder, Anuran Kumar Gayen, Andrew D. Hanson

The paper shows that synonymous mutations, not nonsynonymous ones, drove growth improvements in bacterial THI4 enzymes adapted for plant use through continuous directed evolution.

7 citations

bacteria (other)experimental assay

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