Synthetic BiologybioRxivPreprint
Continuous Directed Evolution of a Plant Histidinol Dehydrogenase to Extend Lifespan
Edmar R. Oliveira-Filho, Anuran Kumar Gayen, Bryan J. Leong…·Andrew D. Hanson
This study uses directed evolution to extend the lifespan of an Arabidopsis enzyme by increasing its abundance and improving its resistance to a toxic intermediate.
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