Y. Nie

Perturbational single-cell profiling of patient tumors defines lineage- and context-specific programs of innate immune resistance

The paper uses patient tumor samples to identify lineage- and context-specific mechanisms of innate immune resistance through perturbational single-cell RNA sequencing.

The evolution of autonomy from two cooperative specialists in fluctuating environments

This study shows that autonomous genotypes can evolve from cooperative microbial specialists in fluctuating environments through horizontal gene transfer.

SON-dependent nuclear speckle rejuvenation alleviates proteinopathies

This study identifies pyrvinium pamoate as a compound that rejuvenates nuclear speckles, improving protein quality control and reducing YAP1 activity, thereby alleviating proteinopathies in pre-clinical models.

High immigration rates critical for establishing emigration-driven diversity in microbial communities

The paper investigates how microbial dispersal affects community diversity under competition, finding that high immigration rates enhance diversity through emigration.

The trade-off between individual metabolic specialization and versatility determines the metabolic efficiency of microbial communities

This study shows that microbial communities with metabolic redundancy outperform both specialized and division-of-labor systems in naphthalene degradation.

Diversity and ecological functions of viruses inhabiting the oil reservoirs

This study identifies a diverse range of viruses in oil reservoirs and their ecological roles in regulating microbial communities and biogeochemical cycles.

Levy statistics define anxiety and depression in mice subjected to chronic stress

This paper identifies Levy statistics as a marker for anxiety and depression in mice under chronic stress, using movement patterns and machine learning for classification.

The maize PLASTID TERMINAL OXIDASE (PTOX) gene controls the carotenoid content of kernels.

This study identifies ZmPTOX1 as a key gene for carotenoid biosynthesis in maize kernels, showing that its disruption reduces carotenoid content while overexpression increases it, particularly beta-carotene.

Keystone taxa responsible for the microbial community stability and performance of activated sludges

The paper identifies keystone taxa in activated sludge microbial communities that enhance stability but reduce function, highlighting the trade-off between stability and performance.

Optical Metabolic Imaging Uncovers Sex- and Diet-dependent Lipid Changes in Aging Drosophila Brain

This study uses optical metabolic imaging to show diet and sex influence lipid metabolism in aging Drosophila brains, revealing IIS pathway involvement.

Single-agent Foxo1 inhibition normalizes glycemia and induces gut β-like cells in streptozotocin-diabetic mice

This study shows that Foxo1 inhibitors reduce blood glucose and generate gut β-like cells in diabetic mice, suggesting they could be an alternative to insulin.

Type IV pilus shapes a "bubble-jet" pattern opposing spatial intermixing of two interacting bacterial populations

This study shows that type IV pili in bacterial consortia reduce spatial intermixing, forming a bubble-jet pattern that affects community productivity.

Even allocation of benefits stabilizes microbial community engaged in metabolic division of labor

The paper develops a theoretical framework and validates it experimentally to show that even allocation of benefits stabilizes microbial communities engaged in metabolic division of labor.

Successful microbial colonization of space using an anti-aggregation strategy

This study shows that anti-aggregation strategies in microbial space colonization enhance competitive success by increasing Space Accessibility, offsetting lower growth rates or initial abundance.

EpicPCR-Directed Cultivation of a Candidatus Saccharibacteria Symbiont Reveals a Type IV Pili-dependent Epibiotic Lifestyle

This study isolates a CPR bacterium using epicPCR and reveals its type IV pili-dependent epibiotic lifestyle and twitching motility.

Sessile bacterium unlocks ability of surface motility through mutualistic interspecies interaction

This paper identifies a mutualistic interaction between non-motile Dietzia and dimorphic Glycocaulis bacteria that enables surface motility through biosurfactant-mediated mechanisms and nutrient exchange.

Substrate traits shape the structure of microbial community engaged in metabolic division of labor

The paper shows that substrate traits determine microbial community structure in metabolic division of labor by using mathematical models and synthetic consortia experiments.