Erik A. Fransén

The paper measures synaptic protein distributions in mouse brains to identify architectural patterns and their developmental changes.

This study shows sleep deprivation reduces excitatory synapse diversity in the cortex and hippocampus of mice, while maintaining total synapse density.

The paper quantifies PSD95 protein lifetime in mouse synapses across lifespan and brain regions, revealing distinct patterns linked to development, behavior, and aging.

The paper shows that synaptome remodelling in mice with Pax6 mutation restores normal developmental trajectory, reversing neurodevelopmental disorder symptoms.

The paper reveals a lifespan program of synaptome architecture changes in the mouse brain, showing differentiation and dedifferentiation phases across brain circuits.