Zhen Qiu

This study shows that traumatic brain injury in mice disrupts and remodels excitatory synapse populations across multiple brain regions, similar to other plasticity-inducing conditions.

The paper introduces PRMix, an augmentation method for improving segmentation of mouse brain regions, and presents a benchmark dataset for anatomical delineation.

The paper introduces NanoSYNMAP to map synaptic nanoarchitecture across the mouse lifespan, revealing how molecular proximity shapes synapse diversity.

The paper measures synaptic protein distributions in mouse brains to identify architectural patterns and their developmental changes.

The paper shows that environmental enrichment and visual deprivation cause large-scale, synapse-type-specific reorganization across the brain, revealing a conserved mechanism of synaptome plasticity.

The paper examines SV2A expression in synapses across mouse and human brains, revealing regional and synaptic variability that challenges current PET imaging interpretations.

The paper shows that synapse diversity in the mouse brain influences regional dynamics, with specific synapse types linked to distinct patterns of brain activity and connectivity.

This study shows sleep deprivation reduces excitatory synapse diversity in the cortex and hippocampus of mice, while maintaining total synapse density.

The paper quantifies PSD95 protein lifetime in mouse synapses across lifespan and brain regions, revealing distinct patterns linked to development, behavior, and aging.

The paper shows that synaptome remodelling in mice with Pax6 mutation restores normal developmental trajectory, reversing neurodevelopmental disorder symptoms.

The paper estimates synapse numbers in the hippocampus and brain-wide using electron microscopy and genetic labeling, finding high densities in isocortex and olfactory areas, and low densities in pallidum and cerebellum.

The paper maps the human synaptome, finding conserved synaptic features between humans and mice despite evolutionary divergence.

The paper reveals a lifespan program of synaptome architecture changes in the mouse brain, showing differentiation and dedifferentiation phases across brain circuits.