Noboru H. Komiyama

The paper discovers a new synaptic structure called the Honeycomb Synapse in the spinal cord, showing its vulnerability in ALS models.

The paper demonstrates that baseline-normalized metrics are essential for accurately interpreting fear memory in mice, showing that conventional freezing scores confound locomotor activity.

The paper introduces NanoSYNMAP to map synaptic nanoarchitecture across the mouse lifespan, revealing how molecular proximity shapes synapse diversity.

The paper shows that environmental enrichment and visual deprivation cause large-scale, synapse-type-specific reorganization across the brain, revealing a conserved mechanism of synaptome plasticity.

This study investigates the developmental plasticity of cochlear inner hair cell ribbon synapses using live-cell imaging, revealing activity-dependent mechanisms in their structural maturation.

The paper investigates the sequential replacement of PSD95 subunits in synaptic supercomplexes, finding that this process is slowest in the cortex where PSD95 has the longest lifetime.

This study shows sleep deprivation reduces excitatory synapse diversity in the cortex and hippocampus of mice, while maintaining total synapse density.

The paper investigates brain pH and lactate levels in animal models of neuropsychiatric disorders, finding decreased pH and increased lactate levels as common features across multiple models.

The paper quantifies PSD95 protein lifetime in mouse synapses across lifespan and brain regions, revealing distinct patterns linked to development, behavior, and aging.

The paper investigates tripartite synapse loss in ALS models and human tissue, finding selective vulnerability of these synapses in both mice and humans.

The paper shows that synaptome remodelling in mice with Pax6 mutation restores normal developmental trajectory, reversing neurodevelopmental disorder symptoms.

This study uses cryo-electron tomography to reveal the 3D molecular architecture of glutamatergic synapses in the adult mammalian forebrain, showing a synaptoplasm rather than a distinct PSD.

The paper reveals a lifespan program of synaptome architecture changes in the mouse brain, showing differentiation and dedifferentiation phases across brain circuits.

The paper develops methods to specifically visualize and isolate endogenous synaptic proteins in mice, revealing differences in PSD95 complex composition across cell types.

The paper identifies synaptic protein combinations that underlie diverse innate and learned behaviors in mice, showing their role in behavioral repertoire expansion and disease susceptibility.

The paper identifies a combinatorial molecular mechanism in synapses that converts nerve impulse patterns into diverse behavioral responses across species and timescales.