Sleep maintains excitatory synapse diversity in the cortex and hippocampus
Dimitra Koukaroudi, Zhen QiuiD, Erik A. FranséniD, Ragini Gokhale, Edita BulovaiteiD, Noboru H. KomiyamaiD, Julie SeibtiD, Seth G. N. GrantiD
Abstract
How sleep deprivation affects cognition remains elusive. Synaptome mapping of excitatory synapses in 125 regions of the mouse brain revealed that sleep deprivation selectively reduces synapse diversity in the cortex and hippocampus. Sleep deprivation targeted specific types and subtypes of excitatory synapses while maintaining total synapse density. Altered synaptic responses to neural oscillations in a computational model suggest that sleep prevents cognitive impairments by maintaining normal brain synaptome architecture.
02 /Specification & Classification
Click any tag to browse matching papers- Citations
- 21
- FWCI
- 5.09
- Field percentile
- top 4%
- Organism
- Approach
Reproducibility ledger
Nobody has reported trying to reproduce this paper yet. Did you replicate an experiment or run the code? Your report saves the next lab a week.
Sign in to file a reproducibility report.
Related papers
- Brief sleep disruption alters synaptic structures among hippocampal and neocortical somatostatin-expressing interneurons
Frank Raven, Alexis Vega-Medina, … Sara J. Aton·SLEEPPeer-reviewed·Mar 14, 2025
- Opposing intrinsic and synaptic plasticity mechanisms stabilize altered cortical networks during sleep deprivation
Richard Joseph Burman, Paul J. N. Brodersen, … Colin J. Akerman·bioRxiv·Jun 8, 2026
- Sleep deprivation following hippocampus-dependent learning downscales synaptic inputs to lateral and medial entorhinal cortex interneurons
Vinodh Balendran, Jiyang Liu, … Sara J. Aton·SLEEPPeer-reviewed·Feb 20, 2026
- Sleep deprivation reduces the density of individual spine subtypes in a branch-specific fashion in CA1 neurons
Youri G. Bolsius, Peter Meerlo, … Robbert Havekes·Journal of Sleep ResearchPeer-reviewed·Jul 15, 2021
- Sleep-dependent upscaled excitability, saturated neuroplasticity, and modulated cognition in the human brain
Mohammad Ali Salehinejad, Elham Ghanavati, … Michael Andreas Nitsche·eLifePeer-reviewed·Jun 6, 2022
- Ultrastructural effects of sleep and wake on the parallel fiber synapses of the cerebellum
Sophia S Loschky, Giovanna Maria Spano, … Chiara Cirelli·eLifePeer-reviewed·Dec 19, 2022