Álvaro González-Rajal

Integrative genomics of the siphonophore Physalia utriculus reveals the regulatory logic of colonial division of labour and the molecular basis of venom activity

This study presents a multi-omic atlas of the siphonophore Physalia utriculus, revealing the regulatory mechanisms of colonial division of labour and the molecular basis of venom activity.

Proteo-transcriptomics and morphometrics of teleost cardiac cells define regulatory networks and exercise-induced cardiomyocyte hypertrophy and hyperplasia

The paper develops a workflow for isolating and profiling adult teleost cardiac cells, revealing exercise-induced hypertrophy and hyperplasia and defining proteo-transcriptomic regulatory networks.

Global genomics of the man-o'-war (Physalia) reveals biodiversity at the ocean surface

The paper sequences 133 Physalia genomes and analyzes citizen-science images to reveal five distinct lineages and four species, with geographic population structure and long-distance dispersal.

Evolutionary conservation of embryonic DNA methylome remodelling in distantly related teleost species

The paper compares DNA methylation dynamics in medaka and zebrafish embryos, showing conserved remodelling patterns without global erasure, and identifies conserved non-canonical methylation reprogramming.

Midkine-a regulates the formation of a fibrotic scar during zebrafish heart regeneration

This study shows that Midkine-a promotes heart regeneration in zebrafish by regulating fibrosis, as its loss leads to persistent collagen scars and blocked regeneration.

Loss of Caveolin-1 and caveolae leads to increased cardiac cell stiffness and functional decline of the adult zebrafish heart

This study shows that loss of Caveolin-1 in zebrafish leads to increased cardiac cell stiffness and impaired heart function, but allows for heart regeneration after injury.