Vaibhav Kumar Jain

This study uses multi-region spatial transcriptomics to identify region-specific transcriptional responses to Aβ plaques in AD, revealing differences in neuronal vulnerability and molecular pathways.

This paper develops a mouse model of HER2-positive breast cancer cerebellar metastases and identifies IL34-induced Arg1+ macrophages as key drivers of tumor growth, showing that targeting CSF1R can reduce metastases.