Juan Cabello

Adulthood depletion of Integrator extends lifespan and healthspan via defective pre-mRNA processing

This study shows that reducing Integrator complex activity in adult C. elegans extends lifespan and healthspan by disrupting RNA processing and mitochondrial function.

Mitochondrial redox homeostasis links organellar stress surveillance to germline and somatic integrity in Caenorhabditis elegans

This study shows that loss of mitochondrial glutathione reductase and thioredoxin reductase in C. elegans causes growth, fertility, and muscle defects, activates a constitutive UPRmt, and alters mitochondrial morphology.

The transsulfuration pathway suppresses the embryonic lethalphenotype of glutathione reductase mutants in Caenorhabditis elegans

The paper shows that inactivating the NMD pathway suppresses the embryonic lethality of gsr-1 mutants in C. elegans by enabling the transsulfuration pathway to compensate for the loss of glutathione reductase function.

Molecular markers characterization determining cell fate specification in an adult neurogenesis model of Alzheimer's disease

The paper characterizes molecular markers during in vitro adult neurogenesis in Alzheimer's disease by analyzing gene expression changes in neural progenitor cells exposed to Aβ1-42.

Loss of glutathione redox homeostasis impairs proteostasis by inhibiting autophagy-dependent protein degradation

This study shows that loss of glutathione redox homeostasis impairs proteostasis by inhibiting autophagy-dependent protein degradation in C. elegans and other organisms.