The transsulfuration pathway suppresses the embryonic lethalphenotype of glutathione reductase mutants in Caenorhabditis elegans
Marina Valenzuela-Villatoro, Eva Gómez‐Orte, David Guerrero‐Gómez, Qing Cheng, Angelina Zheleva, José Antonio Mora-Lorca, Dunja Petrovic, Nigel J. O’Neil, Julián Cerón, Akiko Hatakeyama, Shuichi Onami, A. Ordóñez‐Luque, Cristina Ayuso, Peter Askjaer, Miloš R. Filipović, , Antonio Miranda‐Vizuete
The paper shows that inactivating the NMD pathway suppresses the embryonic lethality of gsr-1 mutants in C. elegans by enabling the transsulfuration pathway to compensate for the loss of glutathione reductase function.
G3 Genes Genomes Genetics · May 7, 2025Peer-reviewedGenetics