PathologyThe Journal of ImmunologyPeer-reviewed
Autoimmune regulator deficiency causes sterile epididymitis and impacts male fertility through disruption of inorganic physiology
Soo Hyun Ahn, Katrina Halgren, Geoffrey Grzesiak…·Margaret Greene Petroff
This study shows that AIRE deficiency causes epididymitis and male infertility through immune-mediated fibrosis, iron deposition, and metal imbalance leading to sperm DNA damage.
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