Author

Matthew V. X. Whelan

University College LondonORCID 0000-0003-0441-3358Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cell Biology· 1 Molecular Biology· 1 Systems Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cell-cell communication· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Research Focus:gene regulatory network inference· 1 Assay:metagenomics· 1

Frequent Co-Authors

Greg J. TowersiD· 3 shared Lucy ThorneiD· 2 shared A. W. Edith ChaniD· 1 shared Abdullah M. SyediD· 1 shared Adolfo García‐SastreiD· 1 shared Adrian James ThrasheriD· 1 shared Adrian PeliniD· 1 shared Ajda RojciD· 1 shared

Activity by Year

2022-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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3 shared papersCell Biology

Greg J. TowersORCID

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3 papers

Recent·Most cited

Cell BiologyMolecular TherapyPeer-reviewedAug 3, 2026

A modified cyclosporine enhances lentivector transduction ex vivo and in vivo by degrading IFITM3

Dara Annett, Bethan J. Critchley, Kate L. Morling…·Greg J. Towers

BG147 enhances lentivector transduction in HSPCs ex vivo and in mouse photoreceptors in vivo by degrading IFITM3.

DOI 10.1016/j.ymthe.2026.07.056

mousebulk RNA-seq

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Systems BiologybioRxivPreprintOct 19, 2022

Global landscape of the host response to SARS-CoV-2 variants reveals viral evolutionary trajectories

Mehdi Bouhaddou, Ann‐Kathrin Reuschl, Benjamin J. Polacco…·Nevan J. Krogan

The paper systematically analyzes proteomic and genomic data of SARS-CoV-2 variants to identify how mutations affect viral gene expression, host interactions, and immune evasion.

14 citations

humanproteomics

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Molecular BiologyRetrovirologyPeer-reviewedJan 24, 2022

HIV-2/SIV Vpx antagonises NF-B activation by targeting p65

Douglas Fink, James Cai, Matthew V. X. Whelan…·Rebecca P. Sumner

This paper demonstrates that HIV-2/SIV Vpx antagonizes NF-κB activation by inhibiting p65 nuclear translocation, independent of known cofactors, and shows this mechanism is conserved across lentiviruses.

14 citations

humanexperimental assay

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