Greg J. Towers

Allosteric capsid inhibitors and their escape mutants drive HIV-1 sensing

This study investigates allosteric capsid inhibitors and their resistance mutants, showing they trigger innate immune responses and may reduce HIV-1 transmission.

A modified cyclosporine enhances lentivector transduction ex vivo and in vivo by degrading IFITM3

BG147 enhances lentivector transduction in HSPCs ex vivo and in mouse photoreceptors in vivo by degrading IFITM3.

Differential time-restricted sensitivity of enveloped viruses to Sec61 translocon blockade

This study investigates how blocking the Sec61 translocon with mycolactone affects the production of enveloped viruses, finding that some viruses resist this inhibition early in infection.

Global landscape of the host response to SARS-CoV-2 variants reveals viral evolutionary trajectories

The paper systematically analyzes proteomic and genomic data of SARS-CoV-2 variants to identify how mutations affect viral gene expression, host interactions, and immune evasion.

HIV-2/SIV Vpx antagonises NF-B activation by targeting p65

This paper demonstrates that HIV-2/SIV Vpx antagonizes NF-κB activation by inhibiting p65 nuclear translocation, independent of known cofactors, and shows this mechanism is conserved across lentiviruses.