Cancer BiologybioRxivPreprint
CDK4/6 inhibition induces a DNA damage-independent senescence-associated secretory phenotype driven by delayed activation of NF-κB
Joanna Lan-Hing Yeung, Justin Rendleman, Lauren Anderson Westcott…·Viviana I. Risca
This study compares the SASP and transcriptional profiles induced by CDK4/6 inhibitors and DNA damage, revealing delayed NF-κB activation in CDK4/6i.
DOI 10.1101/2025.08.25.672139