Ryan L. Sontag

This study uses phosphoproteomics to analyze signaling dynamics in neuronal cells stimulated with insulin and IGFs, identifying key phosphorylation events and pathways involved in actin cytoskeletal regulation.

This paper introduces a nested nanowell chip to improve single-cell proteomics throughput and robustness, demonstrating the ability to quantify ~1500 proteins from ~100 cells with low abundance variation.

MetFish enables LC-MS-based exo-metabolomics analysis in hypersaline samples, quantifying metabolites with high sensitivity and reproducibility in various environments.

This paper demonstrates a wheat-germ cell-free protein expression pipeline that generates high-purity proteins for structural biology analysis.