Sarah Williams

The paper uses activity-targeted metaproteomics to study rare syntrophic bacteria in anaerobic communities, revealing their metabolic activity and a previously hypothesized oxidative glycine pathway.

The paper introduces nanoSPLITS, a platform for simultaneous transcriptome and proteome profiling of single cells, and demonstrates its application in cell cycle regulation and cell type identification.

This study benchmarks label-free and TMT-MS2 methods for spatial proteome mapping, showing label-free provides deeper coverage and higher dynamic range, while TMT-MS2 offers faster throughput.

The paper identifies eQTLs and regulatory networks linking genetic variation to transcriptomic responses in sepsis, highlighting key regulators like HIF1A and CEBPB.

This paper introduces TIFF, a method enhancing single-cell proteomics sensitivity and accuracy by filtering background ions and using 3D MS1 feature matching, achieving deep proteome analysis in single cells.

This paper introduces a nested nanowell chip to improve single-cell proteomics throughput and robustness, demonstrating the ability to quantify ~1500 proteins from ~100 cells with low abundance variation.