Lye Meng Markillie

This study profiles multi-omics data in Picochlorum celeri under CO2 limitation, revealing a CO2-dependent switch in Rubisco subunits and extensive post-translational modifications.

This study applies single-cell proteomics to Arabidopsis leaf mesophyll cells to identify drought stress-related proteins and changes in protein networks.

The paper introduces nanoSPINS, a platform for high-throughput single-cell multiomics that integrates transcriptomic and proteomic profiling from the same cells, demonstrating improved throughput and statistical power.

The paper introduces nanoSPLITS, a platform for simultaneous transcriptome and proteome profiling of single cells, and demonstrates its application in cell cycle regulation and cell type identification.

This study benchmarks label-free and TMT-MS2 methods for spatial proteome mapping, showing label-free provides deeper coverage and higher dynamic range, while TMT-MS2 offers faster throughput.

This paper introduces a nested nanowell chip to improve single-cell proteomics throughput and robustness, demonstrating the ability to quantify ~1500 proteins from ~100 cells with low abundance variation.